DNA gyrase inhibitory activity of ellagic acid derivatives.
Bioorg Med Chem Lett
; 8(1): 97-100, 1998 Jan 06.
Article
en En
| MEDLINE
| ID: mdl-9871636
ABSTRACT
Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs of ellagic acid, which vary in the number and position of the hydroxy groups as well as their replacement with halogens, have been synthesized. The biological activity of these analogs is discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Ácido Elágico
/
Inhibidores Enzimáticos
/
Inhibidores de Topoisomerasa II
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos