Is apoptosis involved in mechanisms to eliminate Onchocerca ochengi during Simulium damnosum s.l. immune response?
Trop Med Int Health
; 3(12): 945-50, 1998 Dec.
Article
en En
| MEDLINE
| ID: mdl-9892279
ABSTRACT
Co-injection of the parasite Onchocerca ochengi and the caspase inhibitors z-VAD.fmk and boc-D.fmk into the natural vector Simulium damnosum s.l. led to significantly increased survival of the parasites. Subsequent in situ apoptosis detection assays demonstrated that in the case of boc-D.fmk the enhanced survival was due to a diminished apoptosis level of the microfilariae in vivo. Additional assays using O. ochengi microfilariae which were coinjected with serine protease inhibitors into S. damnosum s.l. revealed that certain serine protease inhibitors can reduce the level of apoptosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
/
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
3_zoonosis
/
6_skin_diseases
Asunto principal:
Onchocerca
/
Oncocercosis
/
Inhibidores de Cisteína Proteinasa
/
Apoptosis
/
Inhibidores de Caspasas
/
Clorometilcetonas de Aminoácidos
Límite:
Animals
Idioma:
En
Revista:
Trop Med Int Health
Asunto de la revista:
MEDICINA TROPICAL
/
SAUDE PUBLICA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Reino Unido