Intracellular magnesium predicts functional capacity in patients with coronary artery disease.
Cardiology
; 90(3): 168-72, 1998 Dec.
Article
en En
| MEDLINE
| ID: mdl-9892764
ABSTRACT
To determine whether increased intracellular levels of magnesium ([Mg]i) are associated with enhanced functional capacity, we performed symptom-limited exercise treadmill testing on 42 stable coronary artery disease (CAD) patients (37 men, 5 women, mean age 68 +/- 9 years). [Mg]i was found to be an independent and significant predictor of exercise duration (R = 0.31, p = 0.02) in a multivariate stepwise regression model. Patients with > normal [Mg]i of 1.23 microg/mg protein (n = 13) had a significantly greater mean functional capacity, measured in higher achieved metabolic equivalents (10.6 +/- 2.5 vs. 8.9 +/- 2.3, p < 0.05) and exercise duration (9.4 +/- 2.3 vs. 7.9 +/- 2.2 min, p < 0.05) compared to patients with [Mg]i = the normal (n = 29). Thus, functional capacity is greater in stable CAD patients with higher [Mg]i, suggesting that magnesium may play a role in CAD pathophysiology, possibly via ventricular unloading.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucocitos Mononucleares
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Enfermedad Coronaria
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Líquido Intracelular
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Magnesio
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cardiology
Año:
1998
Tipo del documento:
Article