Computational approaches towards the discovery and optimisation of cruzain inhibitors
Mem. Inst. Oswaldo Cruz
; 117: e210385, 2022. tab, graf
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1365149
Biblioteca responsável:
BR1.1
ABSTRACT
The need to develop safer and more efficacious drugs to treat Chagas disease has motivated the search for cruzain inhibitors. Cruzain is the recombinant, truncated version of cruzipain, a cysteine protease from Trypanosoma cruzi with important roles during the parasite life cycle. Several computational techniques have been applied to discover and optimise cruzain inhibitors, providing a molecular basis to guide this process. Here, we review some of the most recent computational studies that provided important information for the design of cruzain inhibitors. Moreover, we highlight the diversity of applications of in silico techniques and their impact.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Contexto em Saúde:
3_ND
Problema de saúde:
3_chagas_disease
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil