Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress
Braz. j. med. biol. res
; 44(7): 707-712, July 2011. ilus, tab
Article
em En
| LILACS
| ID: lil-595698
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BR1.1
ABSTRACT
Metabolic syndrome (MS) is a multifactorial disease involving inflammatory activity and endothelial dysfunction. The aim of the present study was to evaluate the relationship between the changes in lipoperoxidation, in immunological and biochemical parameters and nitric oxide metabolite (NOx) levels in MS patients. Fifty patients with MS (4 males/46 females) and 50 controls (3 males/47 females) were studied. Compared to control (Mann-Whitney test), MS patients presented higher serum levels (P < 0.05) of fibrinogen 314 (185-489) vs 262 (188-314) mg/dL, C-reactive protein (CRP) 7.80 (1.10-46.50) vs 0.70 (0.16-5.20) mg/dL, interleukin-6 3.96 (3.04-28.18) vs 3.33 (2.55-9.63) pg/mL, uric acid 5.45 (3.15-9.65) vs 3.81 (2.70-5.90) mg/dL, and hydroperoxides 20,689 (19,076-67,182) vs 18,636 (15,926-19,731) cpm. In contrast, they presented lower (P < 0.05) adiponectin 7.11 (3.19-18.22) vs 12.31 (9.11-27.27) µg/mL, and NOx levels 5.69 (2.36-8.18) vs 6.72 (5.14-12.43) µM. NOx was inversely associated (Spearman’s rank correlation) with body mass index (r = -0.2858, P = 0.0191), insulin resistance determined by the homeostasis model assessment (r = -0.2530, P = 0.0315), CRP (r = -0.2843, P = 0.0171) and fibrinogen (r = -0.2464, P = 0.0413), and positively correlated with hydroperoxides (r = 0.2506, P = 0.0408). In conclusion, NOx levels are associated with obesity, insulin resistance, oxidative stress, and inflammatory markers. The high uric acid levels together with reactive oxygen species generation may be responsible for the reduced NO levels, which in turn lead to endothelial dysfunction. The elevated plasma chemiluminescence reflecting both increased plasma oxidation and reduced antioxidant capacity may play a role in the MS mechanism.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Resistência à Insulina
/
Endotélio Vascular
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Estresse Oxidativo
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Síndrome Metabólica
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Adiponectina
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Óxido Nítrico
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Brasil