The transgenic Tg.AC mouse model for identification of chemical carcinogens.
Toxicol Lett
; 102-103: 465-71, 1998 Dec 28.
Article
em En
| MEDLINE
| ID: mdl-10022297
ABSTRACT
The Tg.AC (zetaglobin promoted v-Ha-ras) transgenic mouse is being evaluated as a short-term carcinogenicity bioassay. In order to harmonize the evaluation effort in diverse laboratories, an operational bioassay protocol has been established. Data, based principally on retrospective assay of known carcinogens or tumor promoters and non-carcinogens, are presented that support the operational protocol. The Laboratory of Environmental Carcinogenesis and Mutagenesis at the NIEHS has been evaluating transgenic rodent models for utility in differentiating carcinogens from non-carcinogens. Our main approach in this method development effort has been to retrospectively study responses of the models to chemicals of known rodent carcinogenic potential. To this end we have tested mainly chemicals that have been previously studied in chronic rat and/or mouse bioassays by the National Toxicology Program. Development of the data base and assessment of the utility of the models will be immeasurably aided by the availability of a standardized experimental protocol. The purpose of this communication is to present the elements of the Laboratory of Environmental Carcinogenesis and Mutagenesis Tg.AC mouse bioassay protocol and to show experimental results that led to the development of our study design.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Acetato de Tetradecanoilforbol
/
Carcinógenos
/
Genes ras
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos