Persistent antihypertensive effect of oral nitrite supplied up to one year via the drinking water in spontaneously hypertensive rats.
Arzneimittelforschung
; 49(4): 318-23, 1999 Apr.
Article
em En
| MEDLINE
| ID: mdl-10337450
ABSTRACT
The hypothesis was studied whether the chronic administration of nitrite lowers the blood pressure of spontaneously hypertensive rats (SHR) and prevents secondary hypertension-induced organ lesions. For this purpose totally 96 SHR received 50 to 75 mmol/l NaNO2 or equimolar amounts of NaHCO3 in their drinking water during 4, 8 or 12 months. At each point of time arterial blood pressure, determined with the tail cuff method, was significantly lower in the NaNO2-group in comparison to the controls indicating that no significant tolerance towards nitrite had developed. There was also a tendency towards reduced cardiac hypertrophy and renal atrophy in the NaNO2-group, however without reaching the level of significance. Drinking water containing 75 mmol NaNO2/l was not well tolerated by young rats in contrast to 50 mmol/l. Possible beneficial effects of high dietary nitrate/nitrite levels are discussed with respect to the low frequency of hypertension observed in vegetarians.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nitrito de Sódio
/
Hipertensão
/
Anti-Hipertensivos
Limite:
Animals
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Alemanha