All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners.
Trends Cell Biol
; 9(6): 207-10, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10354564
ABSTRACT
Progression through the cell cycle is governed by the periodic activation and inactivation of cyclin-dependent kinase complexes (CDK-cyclins). Although the enzymatic activity of these complexes is regulated tightly, it has recently been demonstrated that an additional facet of cell-cycle control involves the modulation of CDK-cyclin subcellular localization. Recent discoveries include the identification of nuclear transport factors responsible for ferrying some of the CDK-cyclins in and out of the nucleus, the demonstration that phosphorylation can regulate these transport processes and the establishment of potential links between cell-cycle checkpoints and the control of CDK-cyclin subcellular localization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclinas
/
Quinases Ciclina-Dependentes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos