Role of the dorsal raphe nucleus in morphine-induced immediate early gene expression in the rat striatum.
Brain Res
; 842(1): 220-3, 1999 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-10526114
ABSTRACT
Serotonin (5-HT) is thought to be involved in morphine action in the brain. To determine if the periaqueductal gray (PAG) and the dorsal raphe nucleus (DRN) are involved in morphine-induced c-Fos and JunB expression in the caudate-putamen (CPu), the mu receptor antagonist, beta-funaltrexamine (beta-FNA), was unilaterally infused into the PAG adjacent to DRN prior to morphine. Behaviorally, beta-FNA prevented morphine-induced loss of righting and Straub tail. In the CPu of beta-FNA treated rats, morphine-induced c-Fos and JunB were attenuated compared to vehicle-infused rats. These results suggest that morphine acts within the PAG-DRN to exert rapid behavioral effects and to induce c-Fos and JunB in the striatum.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleos da Rafe
/
Neostriado
/
Genes Precoces
/
Analgésicos Opioides
/
Morfina
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos