Conformational aspects of human formylpeptide receptor antagonists.
Arzneimittelforschung
; 49(10): 873-7, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10554666
ABSTRACT
The conformation of several Phe-D-Leu-Phe-D-Leu-Phe analogues was analyzed using infrared absorption and circular dichroism. Their effect on human neutrophils was verified by receptor binding and chemotaxis assays. The results demonstrate that the compounds examined prefer an ordered conformation (beta-turn) in amphipatic environment, and that they are able to antagonize the neutrophil functions evoked by CHO-Met-Leu-Phe.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Receptores de Peptídeos
/
N-Formilmetionina Leucil-Fenilalanina
Limite:
Humans
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Itália
