Medroxyprogesterone acetate increases anthracyclines uptake in chronic lymphatic leukemia cells: role of nitric oxide and lipid peroxidation.
Anticancer Res
; 20(1A): 33-42, 2000.
Article
em En
| MEDLINE
| ID: mdl-10769632
ABSTRACT
Anthracyclines are one of the most used drugs in the therapy of several malignant tumors. Unfortunately, its use is still limited by their cardio-toxicity and by the presence of cancer cells resistant to these drugs. In the present study we evaluated the ability of a chemo-sensitizer agent, MPA (Medroxyprogesterone Acetate), to modify anthracyclines intranuclear uptake in normal leukocytes (NL) and in chronic lymphatic leukemia leukocytes (CLL). Moreover we evaluated the role of lipid peroxidation and nitric oxide (NO) production on antracyclines activity and on their combination with MPA. Our data show that MPA significantly increases anthracyclines uptake only in CLL cells and decreases anthracyclines induced lipid peroxidation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Idarubicina
/
Leucemia Linfocítica Crônica de Células B
/
Peroxidação de Lipídeos
/
Doxorrubicina
/
Acetato de Medroxiprogesterona
/
Leucócitos
/
Lipídeos de Membrana
/
Antibióticos Antineoplásicos
/
Óxido Nítrico
Limite:
Humans
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Itália