A prospective evaluation of empiric versus protocol-based sedation and analgesia.
Pharmacotherapy
; 20(6): 662-72, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10853622
ABSTRACT
STUDY OBJECTIVE:
To compare empiric and protocol-based therapies of sedation and analgesia in terms of pharmacologic cost, effects on mechanical ventilation and intensive care unit (ICU) stay, and quality of sedation and analgesia.DESIGN:
Prospective study.SETTING:
A 24-bed medical-surgical-neurologic ICU. PATIENTS Seventy-two patients evaluated during empiric therapy and 86 during protocol-based therapy. INTERVENTION Assessment of data collected for 4 months before and 5 months after an evidence-based sedation and analgesia protocol was implemented. MEASUREMENTS AND MAINRESULTS:
Protocol adherence rate was 83.7%. The hourly cost (Canadian dollars) of sedation was less with protocol-based therapy ($5.68 +/- 4.27 vs $7.69 +/- 5.29, p<0.01) likely due to increased lorazepam use. Pharmacologic cost savings may be negated since sedation duration tended to be longer (122.7 +/- 142.8 vs 88.0 +/- 94.8 hrs, p<0.1) and extubation may have been delayed (61.6 +/- 97.4 vs 39.1 +/- 54.7 hrs, p=0.13) with protocol use. Duration of ICU stay after sedation was discontinued was not significantly different before and after protocol implementation. With the protocol, however, the percentage of modified Ramsay sedation scores representing discomfort decreased from 22.4 to 11% (p<0.001) and the percentage at a score of 4 increased from 17.2% to 29.6% (p<0.01). The percentage of modified visual analog measurements representing pain decreased from 9.6 to 5.9% (p<0.05) with the protocol. When data were stratified according to duration of sedation, the benefits and delayed extubation associated with protocol-based therapy were limited to patients requiring long-term sedation.CONCLUSION:
Compliance with this protocol reduced drug costs and enhanced the quality of sedation and analgesia for patients requiring long-term sedation. Protocol-based therapy with lorazepam may have delayed extubation but did not delay ICU discharge.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Analgesia
/
Hipnóticos e Sedativos
Tipo de estudo:
Guideline
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Pharmacotherapy
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos