[Effects of mild hypothermia and steroid pulse combination therapy on acute encephalopathy associated with influenza virus infection: report of two cases].
No To Hattatsu
; 32(4): 318-22, 2000 Jul.
Article
em Ja
| MEDLINE
| ID: mdl-10916371
ABSTRACT
We treated two children with influenza-associated acute encephalopathy by a combination of mild hypothermia and steroid pulse therapy. Case 1, a 2-year-and-3-month-old boy, admitted to our hospital 7 days after the onset of central nervous symptoms. The brain MRI-CT revealed laminar cortical necrosis and severe brain edema. EEG showed very low voltage. Brain edema improved by the combination therapy. He had sequelae, but was able to eat. Case 2, a 1-year-and-10-month-old boy, admitted to our hospital 5 days after the onset of central nervous symptoms. Brain MRI showed frontal dominant cortical edema. EEG showed high voltage delta bursts. The combination therapy was effective, but he remained mental handicapped. The outcome was better compared to our previous cases of acute encephalopathy. The combination therapy is intended to counteract cytokines, and was considered to be an effective treatment against acute encephalopathy associated with an influenza virus infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
/
Metilprednisolona
/
Encefalite Viral
/
Influenza Humana
/
Hipotermia Induzida
Tipo de estudo:
Risk_factors_studies
Limite:
Child, preschool
/
Humans
/
Infant
/
Male
Idioma:
Ja
Revista:
No To Hattatsu
Ano de publicação:
2000
Tipo de documento:
Article