Regional distribution of cocaine in postmortem brain of chronic human cocaine users.
J Forensic Sci
; 45(5): 1041-8, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-11005179
ABSTRACT
We measured concentrations of cocaine and its major metabolites (benzoylecgonine, ecgonine methylester, norcocaine, and cocaethylene) in 15 autopsied brain regions of 14 human chronic cocaine users. Only slight differences were observed in concentrations of cocaine and its metabolites amongst the examined brain areas. Although it is likely that some postmortem redistribution of the drug must have occurred, our data are consistent with the possibility that behaviorally relevant doses of cocaine are widely distributed throughout the brain of humans who use the drug on a chronic basis. Consideration should therefore be given to the possible pharmacological and toxicological actions of cocaine in both striatal and extra-striatal brain areas in human users of the drug.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_sustancias_psicoativas
Assunto principal:
Encéfalo
/
Cocaína
/
Inibidores da Captação de Dopamina
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Forensic Sci
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos