Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate.
J Bacteriol
; 182(23): 6824-6, 2000 Dec.
Article
em En
| MEDLINE
| ID: mdl-11073930
ABSTRACT
Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma(B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma(B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma(B) in S. aureus biofilm regulation under environmental stress conditions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator sigma
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Staphylococcus aureus
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Proteínas de Bactérias
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Fatores de Transcrição
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Regulação Bacteriana da Expressão Gênica
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Regulação Enzimológica da Expressão Gênica
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N-Acetilglucosaminiltransferases
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Biofilmes
Idioma:
En
Revista:
J Bacteriol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Alemanha