The role of tumor necrosis factor alpha in chemical-induced hepatotoxicity.
Ann N Y Acad Sci
; 919: 214-20, 2000.
Article
em En
| MEDLINE
| ID: mdl-11083111
ABSTRACT
Only recently have toxicologists come to understand the role of inflammation, and TNFalpha specifically, in classical toxicological processes. This relationship appears fairly complex, as inflammation and proliferation may well be only one facet of a time- and dose-dependent continuum of toxicological and repair processes. Not surprisingly, considerable efforts are being undertaken using our newly found understanding of molecular control to develop specific and safe chemical, biological, and molecular regulators of TNFalpha for potential therapeutic use. Their effectiveness in controlling environmental or occupational diseases has yet to be established.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Necrose Tumoral alfa
/
Doença Hepática Induzida por Substâncias e Drogas
/
Inflamação
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos