Deliberate self-harm and antidepressant drugs. Investigation of a possible link.
Br J Psychiatry
; 177: 551-6, 2000 Dec.
Article
em En
| MEDLINE
| ID: mdl-11102331
ABSTRACT
BACKGROUND:
It is not clear if the frequency of deliberate self-harm (DSH) is the same in patients taking different pharmacological classes of antidepressant drugs.AIMS:
To compare the frequency of DSH in patients who had been prescribed a tricyclic antidepressant (TCA) or a selective serotonin reuptake inhibitor (SSRI) prior to the DSH event.METHOD:
This was a prospective study in 2776 consecutive DSH cases attending an accident and emergency department. The incidence of DSH in TCA-treated cases and SSRI-treated cases is expressed as number of DSH events per 10 000 prescriptions of each antidepressant.RESULTS:
Significantly more DSH events occurred following the prescription of an SSRI than that of a TCA (P<0.001). The occurrence of DSH was highest with fluoxetine and lowest with amitriptyline.CONCLUSIONS:
Merely prescribing safer-in-overdose antidepressants is unlikely to reduce the overall morbidity from DSH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Automutilação
/
Inibidores Seletivos de Recaptação de Serotonina
/
Antidepressivos Tricíclicos
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Br J Psychiatry
Ano de publicação:
2000
Tipo de documento:
Article