Mice lacking interleukin-2 (IL-2)/IL-15 receptor beta chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant.
Infect Immun
; 69(2): 1226-9, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11160028
ABSTRACT
Interleukin-2 (IL-2)/IL-15 receptor beta (IL-15R beta)(-/-) mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2(-/-) mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2(-/-) but not in IL-2/IL-15R beta(-/-) mice infected with Salmonella, suggesting that IL-2/IL-15R beta signaling is important for the generation of protective Th1 cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_neglected_diseases
/
3_zoonosis
Assunto principal:
Salmonelose Animal
/
Receptores de Interleucina-2
/
Interleucina-2
/
Salmonella enterica
Limite:
Animals
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão