The association between smoking and Alzheimer's disease: effects of study design and bias.
Biol Psychiatry
; 49(3): 194-9, 2001 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-11230870
ABSTRACT
In epidemiologic studies, unrecognized bias can contribute to observed results, causing them to be inaccurate. Analytic study designs, such as the case-control and cohort designs, each carry potential for specific forms of bias. The cohort design is not susceptible to many forms of bias that are experienced by case-control studies. A consistent "protective" effect of smoking on Alzheimer's disease was documented by many case-control studies. However, the potential effect of biases cannot be separated from the results. Cohort studies now show that smoking may either be unrelated to Alzheimer's disease onset or possibly generate a modest increased risk. In this review the results and comparisons of various studies and potential biases are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_muertes_prematuras_enfermedades_notrasmisibles
Assunto principal:
Fumar
/
Doença de Alzheimer
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos