Prion protein interconversions.
Philos Trans R Soc Lond B Biol Sci
; 356(1406): 197-200; discussion 200-2, 2001 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-11260800
ABSTRACT
The transmissible spongiform encephalopathies (TSEs), or prion diseases, remain mysterious neurodegenerative diseases that involve perturbations in prion protein (PrP) structure. This article summarizes our use of in vitro models to describe how PrP is converted to the disease-associated, protease-resistant form. These models reflect many important biological parameters of TSE diseases and have been used to identify inhibitors of the PrP conversion as lead compounds in the development of anti-TSE drugs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Príons
/
Doenças Priônicas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Philos Trans R Soc Lond B Biol Sci
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos