Application of MS and NMR to the structure elucidation of complex sugar moieties of natural products: exemplified by the steroidal saponin from Yucca filamentosa L.
Phytochemistry
; 57(3): 489-96, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11393530
ABSTRACT
An approach, using well characterized procedures, is presented that should be of general applicability for the structural elucidation of complex sugar moieties of natural products. The methods used are exemplified by the structure elucidation of a new gitogenin-based steroidal saponin that has a strong leishmanicidal activity similar to preparations used in clinical practice and has been isolated by bioactivity-guided fractionation of the ethanolic extract of Yucca filamentosa L. leaves. The saponin has been characterized as 3-O-((beta-D-glucopyranosyl-(1-->3)- beta-D-glucopyranosy-(1-->2))(alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->3))-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranosyl)-25R,5alpha-spirostan-2alpha,3beta-diol.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Esteroides
/
Produtos Biológicos
/
Carboidratos
/
Liliaceae
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Alemanha