Re-examination of the role of the Brucella melitensis HtrA stress response protease in virulence in pregnant goats.
Vet Microbiol
; 82(1): 91-5, 2001 Sep 03.
Article
em En
| MEDLINE
| ID: mdl-11423199
ABSTRACT
Based on previously reported studies describing the experimental infection of pregnant goats with B. melitensis strain RWP5, we proposed that the HtrA protease plays an important role in the virulence of B. melitensis in its natural ruminant host. Subsequent studies, however, have shown that RWP5 is actually an htrA cycL double mutant. In order to definitively evaluate the role of the B. melitensis htrA in virulence, we constructed an authentic htrA mutant and examined this strain in pregnant goats. The findings of these studies indicate that the contribution of the htrA gene product to the virulence of B. melitensis in its natural host is not as great as was previously proposed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_neglected_diseases
/
3_zoonosis
Assunto principal:
Complicações Infecciosas na Gravidez
/
Serina Endopeptidases
/
Doenças das Cabras
/
Brucella melitensis
/
Proteínas Periplásmicas
/
Proteínas de Choque Térmico
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Vet Microbiol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos