Retinoic acid induction of sialyltransferase activity in neuroblastoma cells of differing sialylation potentials.
Glycoconj J
; 17(11): 781-6, 2000 Nov.
Article
em En
| MEDLINE
| ID: mdl-11443279
ABSTRACT
In order to determine how glycosylation changes associated with cellular differentiation may be influenced by the basal cellular sialylation potential, the effect of retinoic acid (RA)-induced differentiation was investigated in neuroblastoma cells expressing differing levels (and activities) of the alpha2,6(N) sialyltransferase (ST6N) enzyme. The increase in ST activity was proportional to the basal cellular sialylation potentials with the high activity clones showing the greatest increase. This was paralleled by an up-regulation of the level of overall sialoglycoprotein glycosylation level. An increase in the levels of the polysialic acid (PSA) epitope was associated with a parallel increase in the levels of the neural cell adhesion molecule (NCAM) protein backbone although there was no overall change in the PSANCAM ratio following RA treatment.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Siálicos
/
Sialiltransferases
/
Tretinoína
/
Moléculas de Adesão de Célula Nervosa
Limite:
Animals
Idioma:
En
Revista:
Glycoconj J
Assunto da revista:
BIOQUIMICA
/
METABOLISMO
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Reino Unido