[Mechanism of autoantibody production].
Rinsho Byori
; 49(6): 566-70, 2001 Jun.
Article
em Ja
| MEDLINE
| ID: mdl-11452542
ABSTRACT
Autoantibody is a hallmark of autoimmune diseases. In systemic autoimmune diseases such as systemic lupus erythematosus, the target of autoantibodies are mostly nuclear autoantigens like nucleosome and U1RNP. Since immune system comprise autoreactivity to develop itself, the chance of autoantibody appearance should not be rare. Therefore, the disturbance of immunoregulation for nuclear autoantigens might allow the persistence of autoantibody production. The studies of tolerance of nuclear antigens is required to understand autoimmune diseases and to develop more advanced immunotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Doenças Autoimunes
Limite:
Humans
Idioma:
Ja
Revista:
Rinsho Byori
Ano de publicação:
2001
Tipo de documento:
Article