Effects of molsidomine on scopolamine-induced amnesia and hypermotility in the rat.
Eur J Pharmacol
; 426(3): 193-200, 2001 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-11527544
ABSTRACT
Nitric oxide (NO) is hypothesized to be a novel intracellular messenger in the central nervous system. Recently, NO involvement in learning and memory processes has been proposed. Compounds that inhibit nitric oxide synthase, the key synthesizing enzyme, may block cognition, while NO donors may facilitate it. The aim of this study was to assess in the rat the effects of the NO donor molsidomine (2 and 4 mg/kg, i.p.) on memory deficits caused by scopolamine. For this purpose, the object recognition task and the step-through passive avoidance procedure were chosen. In addition, the effects of molsidomine in antagonizing the scopolamine-induced hypermotility were also examined. Scopolamine at 0.2 mg/kg (object recognition) and 0.75 mg/kg (passive avoidance) disrupted acquisition in both the tasks and induced locomotor hyperactivity at the dose of 0.2 mg/kg. Molsidomine at either dose reversed the scopolamine-induced deficits in the object recognition paradigm but did not counteract the hypermotility and the deficits occurred in the passive avoidance test. These results suggest that to some extent, the NO donor molsidomine is involved in memory processing.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escopolamina
/
Vasodilatadores
/
Molsidomina
/
Antagonistas Muscarínicos
/
Amnésia
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Itália