The design and synthesis of purine inhibitors of CDK2. III.
Nucleosides Nucleotides Nucleic Acids
; 20(4-7): 1067-78, 2001.
Article
em En
| MEDLINE
| ID: mdl-11562960
ABSTRACT
Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cyclin E. In this report, the synthesis of a series of piperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biological effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Purinas
/
Adenina
/
Proteínas Serina-Treonina Quinases
/
Quinases Ciclina-Dependentes
/
Quinases relacionadas a CDC2 e CDC28
/
Inibidores Enzimáticos
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos