n-3 polyunsaturated fatty acids and coronary thrombosis.
Lipids
; 36 Suppl: S79-82, 2001.
Article
em En
| MEDLINE
| ID: mdl-11837997
ABSTRACT
Studies of Greenland Eskimos showed that a very high intake of marine n-3 fatty acids markedly inhibited platelet reactivity and suggested that intake of these fatty acids might prevent coronary thrombosis. Later studies with lower, more practical doses of n-3 fatty acids also have shown a platelet inhibitory effect of n-3 fatty acids, albeit fairly marginal. Furthermore, n-3 fatty acids have little effect on measures of blood coagulability and may slightly decrease fibrinolysis. In animal models, n-3 fatty acids often have been shown to inhibit thrombosis, but again the doses have tended to be very high. Finally, there has been little effect of (low-dose) n-3 fatty acids in clinical trials in humans on the incidence of myocardial infarction. Overall, there is little evidence for a major antithrombotic effect of practical doses of n-3 fatty acids on coronary thrombosis. This does not exclude a beneficial effect of n-3 fatty acids on coronary heart disease as suggested from clinical trials, but the major effect may be antiarrhythmic rather than antithrombotic.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombose Coronária
/
Ácidos Graxos Ômega-3
Limite:
Animals
/
Humans
País/Região como assunto:
America do norte
/
Europa
Idioma:
En
Revista:
Lipids
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Dinamarca