Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders.
J Oral Sci
; 43(4): 261-8, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11848193
ABSTRACT
Our previous study indicated that fibroblasts derived from patients reactive to nifedipine might be susceptible to the other calcium-channel blockers (nicardipine, verapamil and diltiazem) in terms of cell proliferation, DNA synthesis, and collagen synthesis. Thus, the present investigation was designed to clarify the cross-reactivity among dihydropyridine calcium-channel blockers (nifedipine, nicardipine, and nisoldipine). Human gingival fibroblasts derived from seven, two, and one patients who developed gingival overgrowth as a result of nifedipine, nicardipine, and nisoldipine medications, respectively, were examined in terms of the effect of calcium-channel blockers (nifedipine, diltiazem, verapamil, and nicardipine) on cell proliferation, DNA synthesis, collagen synthesis, and the number of epidermal growth factor (EGF) receptors. Phenytoin was used as a positive control. With most of the calcium-channel blockers and phenytoin, fibroblasts from patients reactive to nifedipine and nicardipine medications gave a better cell proliferation rate, DNA synthesis, and an increased number of EGF receptors, compared to non-drug-treated control. However, this was not the case for calcium-channel blockers tested in fibroblasts from patients reactive to nisoldipine medication.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Bloqueadores dos Canais de Cálcio
/
Nifedipino
/
Nicardipino
/
Nisoldipino
/
Colágeno
/
Crescimento Excessivo da Gengiva
/
Fibroblastos
/
Receptores ErbB
/
Gengiva
Limite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Oral Sci
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão