[Experimental study on osteoinduction of coral composited artificial bone].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
; 13(3): 141-4, 1999 May.
Article
em Zh
| MEDLINE
| ID: mdl-12080782
ABSTRACT
OBJECTIVE:
To improve the osteoinduction of coral and provide a perfect bone graft substitute for clinical bone defects.METHODS:
By combining coral with collagen and recombinant human bone morphogenetic protein-2(rhBMP-2), coral/collagen/rhBMP-2 composite was obtained. The composite was implanted into the back muscle pouches of mice, and coral/collagen or coral/rhBMP-2 were implanted as control. The osteoinduction of the composite was assessed by histology and image analysis system.RESULTS:
The chondrocyte differentiation and matrix formation were observed in local sites after one week, lamellar bone with bone marrow were formed after 4 weeks, and coral were absorbed partially. The quantity of osteoinduction was time-related and rhBMP-2 dose-related(P < 0.01). Coral/collagen and coral/rhBMP-2 implants did not show any bone or cartilage formation.CONCLUSION:
The coral/collagen/rhBMP-2 composite possesses a superior osteoinduction and will be a new type of bone substitute to be used in orthopedic and maxillofacial surgery.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteogênese
/
Fator de Crescimento Transformador beta
/
Substitutos Ósseos
/
Proteínas Morfogenéticas Ósseas
/
Antozoários
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Ano de publicação:
1999
Tipo de documento:
Article