B cells of aged mice show decreased expansion in response to antigen, but are normal in effector function.
Cell Immunol
; 214(2): 99-109, 2001 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-12088409
ABSTRACT
Increased dysfunction of the immune system with age can be attributed to developmental changes in cell types critical for proper immune responses. Previous studies have shown defects in humoral responses of aged individuals, but have not distinguished between aged T-cell/microenvironment and intrinsic B-cell defects. Here adoptive transfer of antigen-specific transgenic B cells compared early immunopoeisis from young and aged donors in a young recipient environment. B cells from aged donors demonstrated decreased antigen-induced expansion, particularly in the lymph nodes; however, they acquired a germinal center phenotype at frequencies similar to B cells from young donors. Additionally, aged B cells produced equivalent levels of antigen-specific antibody that underwent affinity maturation and isotype switching and demonstrated similar numbers of antibody-secreting cells of switched isotype. Thus, the ability of aged B cells to respond appropriately to T-dependent antigens and differentiate into high-affinity, isotype-switched, antibody-secreting cells appears to be intact.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Subpopulações de Linfócitos B
Limite:
Animals
Idioma:
En
Revista:
Cell Immunol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos