Neurochemical phenotypes of MRF neurons influencing diaphragm and rectus abdominis activity.
J Appl Physiol (1985)
; 94(1): 391-8, 2003 Jan.
Article
em En
| MEDLINE
| ID: mdl-12391091
ABSTRACT
In prior studies that used transneuronal transport of isogenic recombinants of pseudorabies virus, we established that medial medullary reticular formation (MRF) neurons sent collateralized projections to both diaphragm and abdominal muscle motoneurons. Furthermore, inactivation of MRF neurons in cats and ferrets increased the excitability of diaphragm and abdominal motoneurons, suggesting that MRF neurons controlling respiratory activity are inhibitory. To test this hypothesis, the present study determined the neurochemical phenotypes of MRF premotor respiratory neurons in the ferret by using immunohistochemical procedures. Dual-labeling immunohistochemistry combining pseudorabies virus injections into respiratory muscles with the detection of glutamic acid decarboxylase-like immunoreactive and glutamate-like immunoreactive cells showed that both GABAergic and glutamatergic MRF neurons project to respiratory motoneurons, although the latter are more common. These data suggest that the role of the MRF in respiratory regulation is multifaceted, as this region provides both inhibitory and excitatory influences on motoneuron activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Formação Reticular
/
Diafragma
/
Bulbo
/
Reto do Abdome
/
Ácido Glutâmico
/
Ácido gama-Aminobutírico
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
J Appl Physiol (1985)
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos