Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.
Cytogenet Genome Res
; 97(1-2): 100-5, 2002.
Article
em En
| MEDLINE
| ID: mdl-12438746
ABSTRACT
We have characterized a 185-kb contig surrounding a transgene on distal mouse chromosome 11, the insertion of which has caused a recessive phenotype with skeletal malformations. By cDNA selection and sequencing we have found six genes (Lasp1, Rpl23, Mllt6, Pip5k2b, Psmb3, Zfp144), one truncated gene (Mel13), and one pseudogene (Rps15-ps) within this region. The murine Mllt6 gene is new, it was identified by its high homology (90% identity) with the human homologue MLLT6. Psmb3 and Pip5k2b had not yet been assigned to mouse chromosomes. A comparison with the corresponding region on human chromosome 17q12 revealed several small-scale rearrangements during evolutionary divergence within this cluster of densely packed genes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colágeno Tipo I
/
Cromossomos de Mamíferos
/
Mutação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cytogenet Genome Res
Assunto da revista:
GENETICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Áustria