[Studies permeation of puerarin and its phospholipid complex through mouse skin in vitro].

OBJECTIVE: To investigate the skin permeation of puerarin and its phospholipid complex and compare the differences between their permeation rates and cumulative permeation amounts. METHOD: Performing a test of permeation through the mouse skin in vitro in an improved Franz diffusion cell. RESULT: The cumulative permeation amount of phospholipid complex was higher than that of puerarin in the first hour and then increased slowly, meanwhile the permeation rate of puerarin rose higher than that of the complex. CONCLUSION: Phospholipid complex of puerarin can permeate through the mouse skin rapidly up to a certain amount in a short time, then begins to release drug slowly and lastingly.