[Protective mechanism of tianmacuzhi granules in brain].
Zhongguo Zhong Yao Za Zhi
; 26(4): 269-72, 2001 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-12525053
ABSTRACT
OBJECTIVE:
To provide pharmacological evidence for the protective effects of Tianmacuzhi Granules (TMC) in mouse brain in a ischemia--reperfusion model.METHOD:
Receptor binding test of NMDA receptor and M receptor in brain, GPx activity determination in brain and liver effected by different dose of TMC were performed.RESULT:
TMC could reduce the NMDA receptor activity, increase the M receptor activity and GPx activity of cerebral cortex and hippocampus tissues significantly.CONCLUSION:
TMC might antagonize ischemia-reperfusion injury of brain by reducing the glutamate neurotoxicity and increasing the function of cholinergic nerve and effects of anti-peroxidization in brain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Traumatismo por Reperfusão
/
Córtex Cerebral
/
Receptores Muscarínicos
/
Receptores de N-Metil-D-Aspartato
/
Fármacos Neuroprotetores
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Assunto da revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
China