Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus.
Scand J Immunol
; 57(2): 93-8, 2003 Feb.
Article
em En
| MEDLINE
| ID: mdl-12588654
ABSTRACT
The mode of immunosuppressive action of tacrolimus (FK506) and cyclosporin A has been elucidated. Both drugs bind to proteins in the cytoplasm to form complexes, which in turn inhibit the phosphatase activity of calcineurin, an important limiting step in the activation of T cells. The association between drug uptake (pharmacokinetics) and enzyme inhibition (pharmacodynamics) is under current investigation. Great variations in the correlation between blood drug levels and enzyme inhibition could indicate that monitoring calcineurin phosphatase activity for treatment might be superior to monitoring blood drug levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tacrolimo
/
Ciclosporina
/
Monoéster Fosfórico Hidrolases
/
Imunossupressores
Limite:
Humans
Idioma:
En
Revista:
Scand J Immunol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Dinamarca