Role of context in the relationship between form and function: structural plasticity of some PROSITE patterns.
Biochem Biophys Res Commun
; 305(4): 1078-84, 2003 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-12767941
ABSTRACT
True positive hits of PROSITE sequence pattern are expected to have a characteristic three-dimensional structure. The combined sequence-structure attributes of PROSITE patterns can be used for function prediction of an uncharacterized protein with known primary and 3D structure, a situation that might arise in structural genomics projects. We have found specific examples of true hits of PROSITE patterns displaying structural plasticity by assuming significantly different local conformation, depending upon the context. Our work highlights the importance of taking into account all the known distinct conformations of PROSITE patterns, while creating a sensitive 3D template for the pattern, for use in functional annotation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Análise de Sequência de Proteína
/
Motivos de Aminoácidos
/
Bases de Dados de Proteínas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Índia