PT-141: a melanocortin agonist for the treatment of sexual dysfunction.
Ann N Y Acad Sci
; 994: 96-102, 2003 Jun.
Article
em En
| MEDLINE
| ID: mdl-12851303
ABSTRACT
PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. Administration of PT-141 to rats and nonhuman primates results in penile erections. Systemic administration of PT-141 to rats activates neurons in the hypothalamus as shown by an increase in c-Fos immunoreactivity. Neurons in the same region of the central nervous system take up pseudorabies virus injected into the corpus cavernosum of the rat penis. Administration of PT-141 to normal men and to patients with erectile dysfunction resulted in a rapid dose-dependent increase in erectile activity. The results suggest that PT-141 holds promise as a new treatment for sexual dysfunction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Alfa-MSH
/
Disfunção Erétil
Tipo de estudo:
Clinical_trials
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos