[Clinical importance of the CagA and VacA proteins and of the host factores in the development of peptic ulcer in patients infected by Helicobacter pylori]. / Relevancia clínica de las proteínas CagA y VacA y de los factores del huésped en el desarrollo de úlcera péptica en pacientes infectados por Helicobacter pylori.
Rev Clin Esp
; 203(9): 430-3, 2003 Sep.
Article
em Es
| MEDLINE
| ID: mdl-14563256
ABSTRACT
OBJECTIVE:
Demonstrate the role of the virulence factors of Helicobacter pylori, the sex, and tobacco and alcohol use in the development of peptic ulcer in patients infected by H. pylori. PATIENTS ANDMETHODS:
One hundred and seventy-four patient with dyspepsia were studied after they went consecutively for gastroscopy. The diagnosis of infection by H. pylori was carried out by culture and/or histology. Through western-blot the presence of specific anti-H. pylori antibodies was determined. The tobacco and alcohol use data were collected.RESULTS:
One hundred and twenty-five patients (32 with ulceration, 12 with duodenitis and 81 with functional dyspepsia) showed H. pylori infection with anti-bacterium IgG antibodies. The detection of the proteins CagA and VacA, male sex and heavy consumption of alcohol and tobacco were associated with the finding of peptic ulcer. In the multivariate analysis only anti-CagA antibodies (OR 4.1; 95% CI 1.1-15.3; p = 0.036), anti-VacA (OR 3.9; 95% CI 1.4-10.8; p = 0.009) and male sex (OR 3.1; 95% CI 1.2-8.3; p = 0.02) were associated with the ulcerative disease.CONCLUSIONS:
The proteins CagA and VacA, and the male sex, contribute independent risk factors for peptic ulcer in patients infected by H. pylori.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Úlcera Péptica
/
Proteínas de Bactérias
/
Infecções por Helicobacter
/
Antígenos de Bactérias
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Rev Clin Esp
Assunto da revista:
MEDICINA
Ano de publicação:
2003
Tipo de documento:
Article