[Changes and significance of orphanin and serotonin in patients with postpartum depression].
Zhonghua Fu Chan Ke Za Zhi
; 38(12): 727-8, 2003 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-14728841
ABSTRACT
OBJECTIVE:
To study the changes of orphanin (OFQ) and serotonin (5-HT) in the patients with postpartum depression (PPD).METHODS:
Twenty one patients with postpartum depression (PPD group) and 25 healthy lying-in women (control group) were studied. The concentrations of plasma OFQ were measured by radioimmunoassay. The levels of 5-HT were measured with high-pressure liquid chromatography with electrochemical detector.RESULTS:
(1) The levels of plasma OFQ in PPD group were (28.5 +/- 5.8) ng/L, in control group, the levels of OFQ was (10.4 +/- 3.7) ng/L, the levels of OFQ in PPD group were significantly higher than that in the control group (P < 0.01). (2) The levels of plasma 5-HT in PPD group and control group were (1.0 +/- 0.3) micro mol/L and (1.4 +/- 0.4) micro mol/L respectively, the levels of 5-HT in PPD group decreased significantly (P < 0.05). (3) In the PPD group, there was a significant negative correlation between the OFQ and 5-HT level (P < 0.05).CONCLUSION:
The PPD was associated with OFQ and 5-HT, the changes of OFQ levels may play an important role in the pathogenesis of the PPD.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
8_ODS3_consumo_sustancias_psicoactivas
Problema de saúde:
8_opioid_abuse
Assunto principal:
Serotonina
/
Peptídeos Opioides
/
Depressão Pós-Parto
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Zhonghua Fu Chan Ke Za Zhi
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
China