Angiopoietin/tie-2 as mediators of angiogenesis: a role in congestive heart failure?
Eur J Clin Invest
; 34(1): 9-13, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-14984432
ABSTRACT
Angiogenic factors, in particular vascular endothelial growth factor (VEGF) and the angiopoietins, Ang-1 and -2, have recently generated significant interest, especially in oncology. The process of angiogenesis is also thought to occur in response to ischaemic conditions, which lie at the core of cardiovascular disease states such as coronary artery disease and congestive heart failure. However, current data do not conclusively show evidence of angiogenesis per se in these conditions, despite (for example) the presence of high levels of VEGF and Ang-2. High levels of these angiogenic factors in heart disease also have not translated into clinically significant new vessel formation, as in accelerated cancer growth or proliferative retinopathy. Indeed, we would hypothesize that these angiogenic markers--especially the angiopoietins--do not necessarily translate into new vessel formation in congestive heart failure (CHF), but may well reflect disturbances of endothelial integrity in CHF.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Angiopoietina-1
/
Angiopoietina-2
/
Indutores da Angiogênese
/
Insuficiência Cardíaca
/
Neovascularização Patológica
Limite:
Humans
Idioma:
En
Revista:
Eur J Clin Invest
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Reino Unido