Apoptosis in prostate carcinoma before and after neoadjuvant therapy with LH-RH analog.
Ann N Y Acad Sci
; 1010: 789-92, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-15033829
ABSTRACT
This study investigated apoptosis in prostate cancer before and after neoadjuvant treatment with LH-RH analog, demonstrating that this therapy induced high AI and bax and survivin overexpression, thus acting as a proapoptotic agent in prostate cancer. A statistically significant correlation was found between high AI and overexpression of bax protein after therapy. It is probable that this kind of therapy is deeply implicated in promoting the apoptotic intrinsic pathway.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
6_prostate_cancer
Assunto principal:
Neoplasias da Próstata
/
Hormônio Liberador de Gonadotropina
/
Apoptose
/
Proteínas Proto-Oncogênicas c-bcl-2
Limite:
Humans
/
Male
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Itália