Facilitation of A[delta]-fiber-mediated acute pain by repetitive transcranial magnetic stimulation.
Neurology
; 62(12): 2176-81, 2004 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-15210878
ABSTRACT
BACKGROUND:
Repetitive transcranial magnetic stimulation (rTMS) of the motor cortex modulates acute and chronic pain perception. The authors previously showed that rTMS over the primary motor cortex (M1) inhibited capsaicin-induced acute pain ascending through C-fibers.OBJECTIVE:
To investigate the effects of 1-Hz rTMS over M1 on acute experimentally induced pain mediated by Adelta-fibers (i.e., another type of acute pain).METHODS:
The authors examined whether rTMS over M1 affected laser evoked potentials (LEPs) in 13 normal subjects using thulium yttrium-aluminum-garnet laser stimulation. Subjective pain-rating scores and LEPs obtained under three different conditions--rTMS, realistic sham stimulation, and a control condition with no stimulation--were compared.RESULTS:
The authors found that 1-Hz rTMS over M1 significantly aggravated the subjective pain and enhanced the N2-P2 amplitudes compared with the sham or control sessions. Because the pain-rating scores and the N2-P2 amplitudes correlated positively, the N2-P2 amplitudes in the present study can be regarded as the cortical correlate of subjective pain.CONCLUSIONS:
Together with the authors' previous study on C-fiber pain, this facilitatory effect of repetitive transcranial magnetic stimulation on Adelta-fiber-mediated further strengthens the notion of a relationship between repetitive transcranial magnetic stimulation over M1 and pain perception.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Estimulação Magnética Transcraniana
/
Potenciais Evocados
/
Córtex Motor
/
Fibras Nervosas
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Neurology
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Japão