Tachykinin receptors in the equine pelvic flexure.
Equine Vet J
; 29(4): 306-12, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-15338912
ABSTRACT
Tachykinins, of which substance P (SP) is the prototype, are neuropeptides which are widely distributed in the nervous systems. In the equine gut, SP is present in enteric nerves and is a powerful constrictor of enteric muscle; in other species, SP is also known to have potent vasodilatory and pro-inflammatory effects. The specific effects of SP are determined by the subtype of receptor present in the target tissue. There are 3 known subtypes of tachykinin receptors, distinguished by their relative affinities for SP and other tachykinins. The distribution of SP binding sites in the equine pelvic flexure was determined using 125I-Bolton Hunter SP (I-BHSP) autoradiography. Most I-BHSP binding sites were determined to be saturable and specific, therefore presumably representing tachykinin receptors. The greatest degree of I-BHSP binding occurred over very small vessels, and over the muscularis mucosae; I-BHSP binding was also intense over the circular muscle of the muscularis externa and mucosa, and present, although less intense, over the longitudinal muscle of the muscularis externa. Competition of I-BHSP with specific receptor agonists for binding sites in the equine pelvic flexure were used to determine the subtypes of tachykinin receptors present. The neurokinin-1 receptor subtype predominated in the equine pelvic flexure, followed by the neurokinin-3 receptor subtype.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taquicininas
/
Receptores de Taquicininas
/
Colo
/
Cavalos
Limite:
Animals
Idioma:
En
Revista:
Equine Vet J
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos