Mimotopes of conformational epitopes in fibrillar beta-amyloid.
J Neuroimmunol
; 156(1-2): 10-20, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15465592
ABSTRACT
In Alzheimer's disease (AD) beta-amyloid peptide accumulates in the brain in different forms including fibrils. Amyloid fibrils could be recognized as foreign by the mature immune system since they are not present during its development. Thus, using mouse antisera raised against the fibrillar form of Abeta42, we have screened two phage peptide libraries for the presence of foreign conformational mimotopes of Abeta. Antisera from wild type animals recognized predominately peptides with the EFRH motif from Abeta42 sequence, whereas amyloid precursor protein (APP) transgenic mice recognized mainly phage clones that mimic epitopes (mimotopes) within the fibrillar Abeta42 but lack sequence homology with this peptide.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
/
Mimetismo Molecular
/
Epitopos
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2004
Tipo de documento:
Article