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The roles of aldo-keto reductases in steroid hormone action.
Bauman, David R; Steckelbroeck, Stephan; Penning, Trevor M.
Afiliação
  • Bauman DR; Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, 135 John Morgan Building, Philadelphia, Pennsylvania 19104, USA. dbauman@mail.med.upenn.edu
Drug News Perspect ; 17(9): 563-78, 2004 Nov.
Article em En | MEDLINE | ID: mdl-15645014
The human aldo-keto reductase 1C (AKR1C) isozymes are implicated in the pre-receptor regulation of steroid receptors, nuclear orphan receptors and membrane-bound ligand-gated ion channels. Human AKR members that may regulate the local concentration of steroid hormones include: AKR1C1, AKR1C2, AKR1C3, AKR1C4 and AKR1D1. Since, these enzymes are pluripotent, the physiological role for the human AKR1C isozymes is determined by their tissue-specific expression patterns and their substrate availability in target tissues. AKRs work in concert with short-chain dehydrogenases/reductases as switches to control ligand access to nuclear receptors. Consequently, they are potential targets in treating prostate cancer, breast cancer, endometriosis and endometrial cancer.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônios Esteroides Gonadais / Oxirredutases do Álcool Limite: Animals / Humans Idioma: En Revista: Drug News Perspect Assunto da revista: FARMACOLOGIA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônios Esteroides Gonadais / Oxirredutases do Álcool Limite: Animals / Humans Idioma: En Revista: Drug News Perspect Assunto da revista: FARMACOLOGIA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Estados Unidos
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