Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.

ABSTRACT

[structure see text] Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.