New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropica.
J Org Chem
; 70(16): 6196-203, 2005 Aug 05.
Article
em En
| MEDLINE
| ID: mdl-16050677
ABSTRACT
An extensive study of the secondary metabolites produced by the obligate marine actinomycete Salinispora tropica (strain CNB-392), the producing microbe of the potent proteasome inhibitor salinosporamide A (1), has led to the isolation of seven related gamma-lactams. The most important of these compounds were salinosporamide B (3), which is the deschloro-analogue of 1, and salinosporamide C (4), which is a decarboxylated pyrrole analogue. New SAR data for all eight compounds, derived from extensive testing against the human colon carcinoma HCT-116 and the 60-cell-line panel at the NCI, indicate that the chloroethyl moiety plays a major role in the enhanced activity of 1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lactamas
/
Micromonosporaceae
Limite:
Humans
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos