[Thyroglobulin mRNA detection in the follow-up of thyroid carcinomas]. / Détection des ARNm circulants de la thyroglobuline et surveillance des cancers thyroïdiens: revue de la littérature.

ABSTRACT

The follow-up of differentiated carcinomas is based on the detection of thyroglobulin (Tg) in the serum. Tg assays are immunoassays that may be hampered by autoantibodies directed against Tg. To avoid this problem some authors advocated the use of mRNA extraction and RT-PCR amplification. Quantitative methods have been developed to achieve a good analytical sensitivity. These techniques may then be alternative to the Tg assay when anti-Tg antibodies are present in the serum should it be proven they display pronostic values reliable enough for clinical diagnosis use.