Effect of povidone-iodine liposome hydrogel on colonic anastomosis.
Eur Surg Res
; 37(4): 242-5, 2005.
Article
em En
| MEDLINE
| ID: mdl-16260875
ABSTRACT
BACKGROUND:
To evaluate the effect of povidone-iodine liposome hydrogel on colonic anastomosis.METHODS:
70 Wistar-Albino male rats were randomly divided into seven groups. The left colon was transected and end-to-end anastomosis was performed. PVP-I liposome hydrogel was applied around the anastomoses in groups 2 and 5. Colonic bursting pressures and tissue hydroxyproline contents were measured on postoperative days 3 and 7.RESULTS:
PVP-I application did not cause any difference in the bursting pressures on postoperative day 3, but anastomotic strength was significantly increased by the use of PVP-I on postoperative day 7. The use of PVP-I liposome hydrogel had no effect on the level of perianastomotic hydroxyproline on postoperative day 3 but had positive effects on postoperativeday 7.CONCLUSIONS:
We concluded that the beneficial effects of PVP-I liposome hydrogel might be due to the combination of broad-spectrum antimicrobial activity of PVP-I with the drug delivery properties and moisturizing molecular film effects of the liposome hydrogel.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_zoonosis
Assunto principal:
Povidona-Iodo
/
Anastomose Cirúrgica
/
Colo
/
Hidrogel de Polietilenoglicol-Dimetacrilato
/
Lipossomos
/
Anti-Infecciosos Locais
Limite:
Animals
Idioma:
En
Revista:
Eur Surg Res
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Turquia