Synthesis and structure-activity relationships of cephalosporins with C-3' catechol-containing residues.
J Med Chem
; 35(14): 2631-42, 1992 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-1635062
ABSTRACT
Cephalosporins with new catechol substituents at C-3' have been synthesized, including novel compounds with C-3' carbon-carbon bonds. Many of these compounds have high potency against Gram-negative bacteria, in particular against resistant strains like Pseudomonas aeruginosa. Structure-activity relationships are discussed in terms of their dependence on the pKa of the C-3' catechol and also in terms of steric and conformational factors of the C-3' substituent. The best overall properties were found in compounds with a bulky and/or conformationally restricted acidic C-3' catechol.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cefalosporinas
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
França